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| For preclinical compounds, it takes an average of 44 small-molecule candidates to achieve one final approval versus nine biologic drug candidates In Phase II development, it takes an average of 11 small-molecule candidates to achieve one final approval versus four biologic drug candidates Only 19 percent of small-molecule compounds will advance from Phase II to Phase III studies, versus 44 percent for biologics Only 60 percent of small-molecule compounds will successfully complete Phase III studies versus 79 percent for biologics |
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